The Oligodendrocyte Developmental Methylome to Characterize Progenitors for Pediatric Glioma

Award: $300,000 over three years
Principal investigators: Arturo Alvarez-Buylla, PhD and David Rowitch, MD, PhD
Institute: University of California, San Francisco

To better understand pediatric glioma origins, it is important to determine the precise stages of oligodendrocyte progenitor cell (OPC) development targeted by oncogenic mutations. The broad objective of this proposal is to use the methylome as a new index of oligodendrocyte developmental character and use this data to interrogate OPC-like character across different subtypes of human pediatric gliomas from brain stem and forebrain.