PBTF Expands Support for Children's Brain Tumor Network Through Strategic Infrastructure Funding 

The Pediatric Brain Tumor Foundation is proud to continue its partnership with the Children’s Brain Tumor Network through a new $222,000 grant supporting key components of Project RADIANT, CBTN’s next-generation data infrastructure designed to accelerate discovery and translational research across pediatric brain tumors.

These investments build upon CBTN’s mission to create interoperable, high-quality, AI-ready datasets that integrate clinical, molecular, and imaging data across global consortia. PBTF’s FY25 support will fund three complementary initiatives that advance this vision:

1. Streamlined Operations and Data Infrastructure 

This effort strengthens CBTN’s operational and data management backbone through automation of manual workflows, enhanced genomic data pipelines, and new quality control frameworks. These upgrades directly contribute to the Project RADIANT ecosystem by enabling harmonized, machine-readable datasets that integrate with NIH’s CCDI and other national platforms to power AI-driven insights.

2. Clinical Data Collection and Management 

PBTF’s funding will support Clinical Research Coordinator positions responsible for continued patient enrollment, longitudinal record updates, and standardized data capture. This work ensures that every patient record is comprehensive, interoperable, and linkable to biospecimens, imaging, and genomic data.

3. Translational Imaging for Low-Grade Glioma 

This initiative expands and harmonizes pediatric low-grade glioma imaging datasets, connecting radiologic data with matched molecular and clinical records to generate AI-ready, multi-modal resources. By embedding these imaging datasets into Project RADIANT, CBTN will unlock new opportunities for radiogenomic discovery, treatment prediction, and personalized care.

A Shared Commitment to Accelerate Cures

Each of these projects represents PBTF’s unwavering commitment to build the infrastructure that transforms data into discovery and discovery into cures. Together, we reaffirm our shared goal: that no child or family should ever face a brain tumor diagnosis without access to the best science, the most robust data, and the fastest path to cures.