Data Project Investigating HGG Immune Microenvironment During Tumorigenesis and Treatment in Primary Mouse Models

Award: $52,000 over 1 year (2022-2023)
Principal Investigator: Dr. Zachary Reitman, Duke Medical Center

The funding for this project will generate ideal preliminary data to show that the project team has single nucleus and spatial RNA-seq data on their mouse models.  This will provide “anchor data” to compare these models with human tumors, and identify gene signatures to test in the larger proposal when the mice are exposed to different therapies.  Such preliminary data will greatly enhance the proposed NCI grant submission by showing feasibility and characterization of the models.