Biorepository, Stem Cell Lines and Xenografts

Award: $300,000 over three years
Principal investigators: Roger McLendon, MD and Stephen Keir, DrPH, Duke University
Funding partner: The Kyrie Foundation

Funding from the PBTF to the Biorepository Core provides for light microscopic and molecular analysis on all banked specimens in order that researchers have access to histologically and genotypically characterized tumor samples for diagnostic assessments in preclinical and clinical studies. In addition, funding supports ongoing development of pediatric brain tumor cell lines and patient-derived xenografts at Duke that enable the study of phenotypic and functional heterogeneity, the characterization of tumor subtypes, and preclinical drug testing. The resources of the core facilities are made available to researchers at Duke and other institutions.