Research News via University of Pittsburgh School of Medicine and UPMC Children’s Hospital of Pittsburgh

While some pediatric brain tumors can be removed through surgery, others such as diffuse midline gliomas (DMGs) are extraordinarily difficult to treat. Because these tumors are located deep inside the brain, surgery is often impossible. DMGs don’t respond to radiation or other standard treatments either, and children diagnosed with this type of brain tumor are projected to live for less than a year.

New research, funded in part through the Pediatric Brain Tumor Foundation, shows promise for treating these especially deadly tumors.

In a paper published in Nature Cancer this week, physician-scientists from the University of Pittsburgh School of Medicine Department of Neurological Surgery and UPMC Children’s Hospital of Pittsburgh discovered that DMG tumors are uniquely dependent on methionine – an amino acid that humans must receive from food. Developing drugs that restrict methionine-processing specifically in the brain tumor, but not the rest of the body could pave the way for new non-invasive treatments.

PBTF supported this discovery through our Early Career Development funding of Dr. Stephen Mack at St. Jude’s Children’s Research Hospital. As part of our strategy to accelerate pediatric-first brain tumor research, PBTF’s multi-year Early Career Development grants ensure that talented scientists like Dr. Mack have the funding needed to become fully independent investigators while fostering collaborations to pursue new therapies for children battling the deadliest childhood cancer.

You can make more discoveries possible by joining the PBTF community. Sign up today to stay on top of pediatric brain tumor news, resources for patient families, and ways to get involved.

 

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Pediatric Cancer Neuropsychological Needs Assessment Act Introduced in New York Legislature

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A new bill introduced in the New York State Legislature by Senator Shelley B. Mayer and Assembly Member Christopher Burdick will help remove some of the barriers standing between children with cancer and the learning accommodations they need to succeed in school. The Pediatric Cancer Neuropsychological Needs Assessment Act (NY State S.8750) would require insurers to provide coverage for neuropsychological assessments for children diagnosed with cancer that affects brain development or function.

The Pediatric Brain Tumor Foundation Welcomes Dr. Sanjay Gupta to Its Board of Directors

Press Release

The Pediatric Brain Tumor Foundation Welcomes Dr. Sanjay Gupta to Its Board of Directors

The Pediatric Brain Tumor Foundation (PBTF) is proud to welcome Dr. Sanjay Gupta, CNN’s chief medical correspondent, to the PBTF’s Board of Directors. Dr. Gupta will bring his wide-ranging experiences in medical practice and journalism, including as associate chief of the neurosurgery service at Grady Memorial Hospital in Atlanta, associate professor of neurosurgery at the Emory University School of Medicine, and chief medical correspondent for CNN, to bear as a valuable and expert advocate for pediatric brain tumor patients, survivors, and their families.

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