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High-Grade Astrocytomas

Astrocytomas are the most common type of childhood glial cell cancer (glioma). High-grade astrocytomas - also called high-grade gliomas - tend to grow and spread more quickly than low-grade astrocytomas.


About high-grade astrocytomas

High-grade astrocytomas are aggressive tumors, a type of high-grade glioma (brain tumors that form in glial cells) and include anaplastic astrocytomas (grade 3) and glioblastomas (grade 4).  Treatment in children aims to remove or control the tumor, relieve symptoms, and prolong survival.  Standard treatment includes surgery, radiation therapy with follow-up chemotherapy and as needed molecular targeted therapy (precision medicine).

Like low-grade gliomas, high-grade gliomas start in star-shaped brain cells called astrocytes, a type of glial cell.

High-grade vs. low-grade brain tumors

The term high-grade is used to describe cancer cells and tissues that look abnormal under a microscope.

High-grade tumors tend to grow and spread more quickly than low-grade tumors.

High-grade tumors usually have a worse chance of recovery than low-grade cancers. They may need treatment right away and treatment that is more aggressive.

Knowing whether a pediatric brain tumor is low-grade or high-grade may help guide your child’s treatment.

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